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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract:

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an importantcontextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelialcells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypicoverview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 313-329 doi: 10.1007/s11684-020-0737-1

Abstract: The epithelial–mesenchymal transition (EMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis

Keywords： epithelial−mesenchymal transition     H. sinensis mycelium     midkine     pulmonary fibrosis    

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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymaltransition (EMT) is regarded as the mechanistic basis for the behavior of cancer cells.

Keywords： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte–endothelial

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model

Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 204-210 doi: 10.1007/s11684-009-0039-0

Abstract: There was less E-Cadherin in renal tubular epithelial cells in the empty control group but more Vimentinrenal allograft and attenuates graft fibrosis, which may be correlated with a decreased renal tubular epithelialmesenchymal transition, a decreased infiltration of CD4 T lymphocyte, CD8 T lymphocytes and ED-1

Keywords： anti-ERK2     renal transplantation     epithelial mesenchymal transition     chronic allograft nephropathy    

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Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 138-151 doi: 10.1007/s11684-018-0627-y

Abstract: As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have

Keywords： mesenchymal stem cell     clinical transition     immune disorders    

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Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial source

Keywords： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: to compare cell growth characteristics, ciliated cell differentiation, and function of human nasal epithelialHuman nasal mucosa of the uncinate process was obtained by endoscopy and epithelial cell cultures wereEpithelial cell growth characteristics were observed by inverted phase contrast microscopy.and differentiated cell composition, with both types of cultures comprising ciliated and non-ciliated epithelialnon-ciliated cells, which have growth characteristics and ciliary activity similar to those of nasal epithelial

Keywords： ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

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Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 33-39 doi: 10.1007/s11684-011-0114-1

Abstract: Mesenchymal stem cells (MSCs), for example, have been shown to play a role in tissue repair.

Keywords： mesenchymal stem cells     migration     molecular mechanisms     signaling pathway    

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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract:

A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively

Keywords： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 20-29 doi: 10.1007/s11684-014-0371-x

Abstract: As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs

Keywords： cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

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Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous properties

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

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Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 372-378 doi: 10.1007/s11684-011-0164-4

Abstract: Mesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest over

Keywords： mesenchymal stem cells     differentiation     immunomodulation     regenerative medicine    

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: In vitro, the indirect coculture of macrophages derived from THP-1 and human corneal epithelial

Keywords： dry eye disease     glycolytic reprogramming     pyroptosis     inflammation     2-DG    

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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 94-100 doi: 10.1007/s11684-011-0116-z

Abstract:

Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease

Keywords： placenta stem cells     treatment of type 2 diabetes    

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Title Author Date Type Operation

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model

Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG

Journal Article

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Journal Article

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Journal Article

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Journal Article

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Journal Article

Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial

Journal Article

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Journal Article